0:00 - ♫ Numbers ♫
0:07 - Intro
0:25 - How to
0:56 - Clover Installation
1:05 - Copy NVMExpress
1:43 - Edit boot delay.
2:03 - Shutdown / Reboot

Motherboard : ASRock QC5000-ITX (quad core Amd)
Also worked on an hp pro 3500 (intel 3rd gen i5)

pcie x4 or greater adapter is recommended, lower than x4 = lower read/write speeds.

If you run into an issue the forum is still active so you might be able to find a solution there. 
Guide : https://winraid.level1techs.com/t/guide-nvme-boot-without-modding-your-uefi-bios-clover-efi-bootloader-method/31665

The guide states
 " Advantages:
+ Theoretically, it should work on every BIOS and UEFI. Not restricted in terms by the BIOS/UEFI-vendor. (Yes, by BIOS I mean even legacy BIOS)"
The oldest system I've done it on was one with a 3rd gen Intel chip (i7 3770) and I'm not sure if that was a legacy BIOS machine or UEFI.

Boot disk utility site : http://cvad-mac.narod.ru/index/bootdiskutility_exe/0-5
Boot disk utility download : http://cvad-mac.narod.ru/files/BDU_v2.1.2020.028b.zip

Steps:
-- Install the ssd onto the pcie adapter and slappity slap it into a free slot in the PC.
-- Boot into the old Windows and download / run the boot disk utility.
-- Boot disk utility download : http://cvad-mac.narod.ru/files/BDU_v2.1.2020.028b.zip
-- Select format on your usb stick using the boot disk utility. (usb must be formatted GPT, not MBR; partition wizard lets you check how it's formatted). This will install clover boot on  the usb stick.
-- Copy necessary file to proper locations
-- Reboot the PC and change bios to boot into the usb stick (select efi when applicable). 
--  Clover will start; the nvme should be the default selection to boot from. Boot from the nvme ssd and Bob's your uncle.

--- Side note : you can use Macrium Reflect to clone the usb stick to your old drive to boot it from there instead.

First time I did this I installed windows on the nvme drive using the same PC that doesn't have native nvme support. It was able to install Windows but not boot from it (windows installer has nvme drivers so was able to detect and install).

Other side note : Ventoy is my preferred tool to make a bootable OS installation USB stick. You only run it once and after that you can drag and drop OS ISO images onto the USB drive without having to run the program again.